The United States has the highest number of drug use disorder deaths in the world.

• In the United States, 5.47% of the population had an alcohol or drug use disorder, second only to Russia with 5.93%.

• For the prevalence of alcohol use disorder, the United States ranks No. 3 (2.04%) behind Russia (4.73%) and Ukraine (4.69%).

• The U.S. rate of death from drug use disorders tops the list with 18.75 per 100k. The world average is 2.08 per, and the second highest country is Libya, with 8.2 per 100k.

(U.S. And International Addiction Statistics & Facts | FHE Health, n.d.)